By Sriparna Roy
Bengaluru — Gilead said on Tuesday it will acquire German-based Tubulis for up to $5bn, as the US drugmaker looks to boost its pipeline with a lucrative class of experimental cancer drugs referred to as “guided missiles”.
This is the latest purchase in Gilead’s acquisition spree. The company has been expanding beyond its key areas for growth amid looming patent expiries and declining sales of its Covid-19 treatment.
In February, the drugmaker bought partner Arcellx for up to $7.8bn, its biggest deal since 2020, to strengthen its lineup of cancer treatments. Last month, it agreed to acquire privately held biotech firm Ouro Medicines in a deal worth more than $2bn to expand its pipeline of immune disorder drugs.
With the latest deal, Gilead will get access to Tubulis’ drugs, which belong to the class called antibody-drug conjugates (ADC), popularly known as “guided missiles”, which deliver chemotherapy directly to cancer cells while minimising harm to healthy tissue.
Tubulis’ lead asset, TUB-040, which binds to NaPi2b, a protein found in certain cancer cells, is in early-stage development for a type of ovarian cancer and non-small cell lung cancer. Another experimental drug, TUB-030, is being studied across various solid tumour types.
“The agreement to acquire Tubulis is a significant milestone in Gilead’s progress in oncology,” said Gilead CEO Daniel O’Day.
Under the terms of the deal, Gilead will acquire all of the outstanding equity of Tubulis for $3.15bn in upfront cash, payable at closing, and up to $1.85bn in milestone payments.
The companies have previously entered into licensing agreements to develop ADCs. Tubulis also has a partnership with Bristol-Myers Squibb
Following the close of the transaction, which is expected in the second quarter of 2026, Tubulis will operate as an ADC research organisation within Gilead.
